2′-C-Methyluridine phosphoramidite: A new building block for the preparation of RNA analogues carrying the 2′-hydroxyl group

A new stereoselective synthesis of 2′-C-methyluridine was carried out. The preparation of the corresponding protected phosphoramidite suitable for the automated synthesis of oligonucleotides, including the regioselective protection of the 2′-hydroxyl group, is described here. This new modified nucle...

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Detalles Bibliográficos
Autores principales:	Gallo, M., Monteagudo, E., Cicero, D.O., Torres, H.N., Iribarren, A.M.
Formato:	JOUR
Materias:	2′-C-alkylnucleotides RNA analogues Sugar conformation 2' c methyluridine 2' c methyluridine phosphoramidite 3',5' di o acetyl 2' c methyluridine 3',5' di o acetyl 2' o tetrahydropyranyl 2' c methyluridine 3',5' o (tetraisopropyldisiloxane 1,3 diyl) 2' c methyluridine 5' o dimethoxytrityl 2' c methyluridine 3 o (2 cyanoethyl n,n diisopropyl phosphoramidite) hydroxyl group oligonucleotide phosphoramidic acid derivative RNA derivative unclassified drug uridine derivative article chemical modification chemical reaction chemical structure priority journal reaction analysis stereochemistry synthesis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00404020_v57_n27_p5707_Gallo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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