Synthesis of 4-azasteroids by an intramolecular Ugi reaction

In this paper we report the use of an intramolecular Ugi reaction to synthesize new 4-azacholestanes diversely substituted both at N-4 and C-5. Both the scope and the stereochemical outcome of this approach were studied by varying the nature of the components necessary for this multicomponent reacti...

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Detalles Bibliográficos
Autores principales: Alonso, F., Acebedo, S.L., Bruttomesso, A.C., Ramírez, J.A.
Formato: JOUR
Materias:
4-Azacholestanes
Azasterols
Multicomponent reaction
Ugi reaction
4 (2' (1h benzo[b]azol 3 yl)ethyl) 5 n cyclohexylcarboxamido 4 aza 5alpha cholestan 3 one
4 (2' (1h benzo[b]azol 3 yl)ethyl) 5 n cyclohexylcarboxamido 4 aza 5beta cholestan 3 one
4 (2' phenylethyl) 5 n cyclohexylcarboxamido 4 aza 5alpha cholestan 3 one
4 (2' phenylethyl) 5 n cyclohexylcarboxamido 4 aza 5beta cholestan 3 one
4 (3' azidopropyl) 5 n (ethoxycarbonylmethylen)carboxamido 4 aza 5alpha cholestan 3 one
4 (3' azidopropyl) 5 n (ethoxycarbonylmethylen)carboxamido 4 aza 5beta cholestan 3 one
4 benzyl 5 n (diethoxyphosphorylmethylen)carboxamido 4 aza 5alpha cholestan 3 one
4 benzyl 5 n (diethoxyphosphorylmethylen)carboxamido 4 aza 5beta cholestan 3 one
4 benzyl 5 n (methoxycarbonylmethylen)carboxamido 4 aza 5alpha cholestan 3 one
4 benzyl 5 n (methoxycarbonylmethylen)carboxamido 4 aza 5beta cholestan 3 one
4 benzyl 5 n cyclohexylcarboxamido 4 aza 5alpha cholestan 3 one
4 benzyl 5 n cyclohexylcarboxamido 4 aza 5beta cholestan 3 one
4 butyl 5 n cyclohexylcarboxamido 4 aza 5alpha cholestan 3 one
4 butyl 5 n cyclohexylcarboxamido 4 aza 5beta cholestan 3 one
4 propargyl 5 n (ethoxycarbonylmethylen)carboxamido 4 aza 5alpha cholestan 3 one
4 propargyl 5 n (ethoxycarbonylmethylen)carboxamido 4 aza 5beta cholestan 3 one
azasteroid
cholestane derivative
unclassified drug
article
chemical reaction
drug synthesis
drug targeting
stereochemistry
substitution reaction
Azasteroids
Magnetic Resonance Spectroscopy
Molecular Conformation
Spectrometry, Mass, Electrospray Ionization
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0039128X_v73_n12_p1270_Alonso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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