Synthesis of new C-25 and C-26 steroidal acids as potential ligands of the nuclear receptors DAF-12, LXR and GR
A new methodology to obtain C-25 and C-26 steroidal acids starting from pregnenolone is described. Construction of the side chain was achieved by applying the Mukaiyama aldol reaction with a non-hydrolytic work-up to isolate the trapped silyl enol ether with higher yields. Using this methodology we...
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Autores principales: | , , , |
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Formato: | JOUR |
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Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0039128X_v121_n_p40_Dansey |
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