Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin

Pregnenolone, medroxyprogesterone (MPA) and melengestrol (MLA) caused a significant decrease of brain stem serotonin (5-HT) in the adult female rat, without modifying the content of 5-hydroxy indoleacetic acid (5-HIAA). Only MPA and MLA increased the liver tryptophan pyrrolase (LTP) activity. Chlorm...

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Detalles Bibliográficos
Autores principales: Izquierdo, J.A., Savini, C., Borghi, E., Rabiller, G., Costas, S., Justel, E.
Formato: JOUR
Materias:
16alpha methylpregnenolone
chlormadinone
corticotropin
deoxycorticosterone
enzyme
hydroxyprogesterone
medroxyprogesterone
medroxyprogesterone acetate
melengestrol acetate
pregnenolone
progesterone acetate
serotonin
tetracosactide
tryptophan 2,3 dioxygenase
unclassified drug
animal experiment
article
brain stem
central nervous system
drug antagonism
drug comparison
endocrine system
rat
subcutaneous drug administration
Animals, Laboratory
Biology
Clinical Research
Contraception
Contraceptive Agents, Female > pharmacodynamics
Contraceptive Agents, Progestin > pharmacodynamics
Contraceptive Agents > pharmacodynamics
Family Planning
Hormones
Laboratory Procedures
Literature Review
Medroxyprogesterone Acetate > pharmacodynamics
Melengestrol Acetate > pharmacodynamics
Physiology
Research Methodology
Serotonin
Adrenalectomy
Adrenocorticotropic Hormone
Animals
Brain Stem
Fasting
Female
Hydroxyindoleacetic Acid
Medroxyprogesterone
Monoamine Oxidase
Rats
Tryptophan
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00316989_v10_n7_p643_Izquierdo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Pregnenolone, medroxyprogesterone (MPA) and melengestrol (MLA) caused a significant decrease of brain stem serotonin (5-HT) in the adult female rat, without modifying the content of 5-hydroxy indoleacetic acid (5-HIAA). Only MPA and MLA increased the liver tryptophan pyrrolase (LTP) activity. Chlormadinone, in spite of its similar chemical structure, had no effect. Both total and free plasma tryptophan were not modified, except the latter which decreased when MPA was injected. The steroids herein studied had no effect on brain stem tryptophan and monoamino oxidase (MAO) system activity. The effect of MPA on 5-HT was antagonized in fasting, adrenalectomized and normal rats injected with ACTH. These results suggest that ACTH would participate in the effect of MPA on brain stem 5-HT. © 1978 The Italian Pharmacological Society.

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