Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage

Abstract Amyloid precursor protein (APP) shedding yields the Alzheimer's disease (AD)-related peptide amyloid β (Aβ) through β- and γ-secretase cleavage. Alternatively, α-secretase cleavage generates a soluble and neuroprotective fragment (sAPPα) while precludes the production of Aβ. Although m...

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Detalles Bibliográficos
Autores principales:	Durand, D., Carniglia, L., Beauquis, J., Caruso, C., Saravia, F., Lasaga, M.
Formato:	JOUR
Materias:	Amyloid precursor protein Astrocytes Hippocampus Keywords Metabotropic glutamate receptor 3 PDAPP-J20 mice Secretases ADAM protein ADAM10 endopeptidase alpha secretase amyloid precursor protein beta secretase metabotropic receptor 2 metabotropic receptor 3 peroxisome proliferator activated receptor gamma protein ADAM17 unclassified drug 4 amino 2 oxabicyclo[3.1.0]hexane 4,6 dicarboxylic acid amino acid amino acid receptor stimulating agent APP protein, human fused heterocyclic rings metabotropic receptor secretase Alzheimer disease animal cell animal experiment animal model animal tissue article astrocyte controlled study enzyme activation enzyme release female molecular pathology mouse nonhuman nucleotide sequence priority journal protein cleavage protein expression protein function rat receptor upregulation aging agonists animal C57BL mouse cell culture drug effects genetics hippocampus human metabolism mutation transgenic mouse Wistar rat Aging Amino Acids Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Animals Bicyclo Compounds, Heterocyclic Cells, Cultured Excitatory Amino Acid Agonists Female Humans Mice Mice, Inbred C57BL Mice, Transgenic Mutation Rats Rats, Wistar Receptors, Metabotropic Glutamate
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00283908_v79_n_p180_Durand
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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