Block of the α9 nicotinic receptor by ototoxic aminoglycosides

In the present study, we report that the α9 nicotinic acetylcholine receptor (nAChR) expressed in Xenopus laevis oocytes is reversibly blocked by aminoglycoside antibiotics. The aminoglycosides tested blocked the α9 nAChR in a concentration-dependent manner with the following rank order of potency:...

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Detalles Bibliográficos
Autores principales: Rothlin, C.V., Katz, E., Verbitsky, M., Vetter, D.E., Heinemann, S.F., Elgoyhen, A.B.
Formato: JOUR
Materias:
Aminoglycosides
Hair cells
Nicotinic receptors
Ototoxicity
acetylcholine
amikacin
aminoglycoside
aminoglycoside antibiotic agent
gentamicin
kanamycin
neomycin
nicotinic receptor
streptomycin
1,2 bis(2 aminophenoxy)ethane N,N,N',N' tetraacetic acid acetoxymethyl ester
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester
antiinfective agent
calcium
chelating agent
Chrna9 protein, rat
drug derivative
egtazic acid
nicotinic receptor blocking agent
animal cell
article
binding site
controlled study
Corti organ
drug potency
drug receptor binding
hair cell
nonhuman
oocyte
ototoxicity
priority journal
receptor blocking
Xenopus laevis
animal
chemically induced disorder
drug effect
electrophysiology
electrostimulation
hearing disorder
metabolism
olivary nucleus
rat
Xenopus
Animals
Anti-Bacterial Agents
Calcium
Chelating Agents
Egtazic Acid
Electric Stimulation
Electrophysiology
Gentamicins
Hearing Disorders
Nicotinic Antagonists
Olivary Nucleus
Oocytes
Rats
Receptors, Nicotinic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00283908_v39_n13_p2525_Rothlin
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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