Characterization of flunitrazepam and beta-carboline high affinity binding in bovine pineal gland

High affinity binding of3H-fiunitrazepam (FNZP) to crude membrane preparations of bovine pineal membranes was examined by a rapid filtration procedure through Whatman GFB paper. At 0 °C binding reached equilibrium in about 20 min. Scatchard analysis of data at equilibrium revealed a single populatio...

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Detalles Bibliográficos
Autores principales: Lowenstein, P.R., Cardinali, D.P.
Formato: JOUR
Materias:
Barbiturates
Benzodiazepine binding
GABA
Pineal gland
β-Carboline binding
4 aminobutyric acid
4' chlorodiazepam
barbituric acid derivative
benzodiazepine
clonazepam
flumazenil
flunitrazepam
pentobarbital
radioisotope
animal cell
beta carboline 3 carboxylic acid ethyl ester h 3
cattle
cell membrane
central nervous system
drug receptor binding
endocrine system
flunitrazepam h 3
nonhuman
pharmacokinetics
pineal body
Animal
Anti-Anxiety Agents, Benzodiazepine
Benzodiazepines
Binding Sites
Carbolines
Cattle
Comparative Study
Flunitrazepam
gamma-Aminobutyric Acid
In Vitro
Indoles
Kinetics
Pentobarbital
Pineal Gland
Rats
Species Specificity
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00283835_v37_n2_p150_Lowenstein
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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