IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

Tumours evade immune control by creating hostile microenvironments that perturb T cell metabolism and effector function 1–4 . However, it remains unclear how intra-tumoral T cells integrate and interpret metabolic stress signals. Here we report that ovarian cancer—an aggressive malignancy that is re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Song, M., Sandoval, T.A., Chae, C.-S., Chopra, S., Tan, C., Rutkowski, M.R., Raundhal, M., Chaurio, R.A., Payne, K.K., Konrad, C., Bettigole, S.E., Shin, H.R., Crowley, M.J.P., Cerliani, J.P., Kossenkov, A.V., Motorykin, I., Zhang, S., Manfredi, G., Zamarin, D., Holcomb, K., Rodriguez, P.C., Rabinovich, G.A., Conejo-Garcia, J.R., Glimcher, L.H., Cubillos-Ruiz, J.R.
Formato:	JOUR
Materias:	gamma interferon glutamine messenger RNA protein IRE1 protein IRE1alpha unclassified drug X box binding protein 1 amino acid transporter ERN1 protein, human glucose IFNG protein, human protein serine threonine kinase ribonuclease XBP1 protein, human animal cell animal model animal tissue ascites fluid ascites tumor CD4+ T lymphocyte controlled study cytokine production down regulation endoplasmic reticulum stress female gene expression regulation glucose transport human human cell human tissue IFNG gee Letter lymphocyte function lymphocytic infiltration mitochondrial respiration mouse nonhuman ovary cancer priority journal protein glycosylation signal transduction transcriptomics upregulation animal ascites biosynthesis cancer transplantation cell respiration cytology deficiency disease exacerbation genetics glycosylation immunology metabolism metastasis mitochondrion ovary tumor pathology survival rate T lymphocyte tumor escape unfolded protein response Mus Amino Acid Transport Systems, Basic Animals Ascites Cell Respiration Disease Progression Endoplasmic Reticulum Stress Endoribonucleases Female Gene Expression Regulation, Neoplastic Glucose Glutamine Glycosylation Humans Interferon-gamma Mice Mitochondria Neoplasm Metastasis Neoplasm Transplantation Ovarian Neoplasms Protein-Serine-Threonine Kinases Signal Transduction Survival Rate T-Lymphocytes Tumor Escape Unfolded Protein Response X-Box Binding Protein 1
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00280836_v562_n7727_p423_Song
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
Publicado: (2018)

Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis
por: Jurado, J.O., et al.

Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis
Publicado: (2008)

Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis
Publicado: (2017)

Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis
por: Méndez-Huergo, S.P., et al.

Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments
por: Ilarregui, Juan Martín
Publicado: (2009)

Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments
por: Rabinovich, G.A., et al.

IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
Publicado: (2009)

IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
por: Pasquinelli, V., et al.

N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins
por: Medus, M.L., et al.

N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins
Publicado: (2017)

Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments
por: Soldati, R., et al.

Inhibitor of growth 1 (ING1) acts at early steps of multiple DNA repair pathways
Publicado: (2013)

Inhibitor of growth 1 (ING1) acts at early steps of multiple DNA repair pathways
por: Ceruti, J.M., et al.

Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments
por: Salatino, Mariana
Publicado: (2012)

Cyclase-associated protein 1 (CAP1) is a prenyl-binding partner of Rap1 GTPase
Publicado: (2018)

Cyclase-associated protein 1 (CAP1) is a prenyl-binding partner of Rap1 GTPase
por: Zhang, X., et al.

Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses
por: Hernández Del Pino, R.E., et al.

Glycobiology of cell death: When glycans and lectins govern cell fate
por: Lichtenstein, R.G., et al.

An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein
Publicado: (2010)

An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein
por: García, C.C., et al.

Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses
Publicado: (2017)

Tissue Transglutaminase on Trophoblast Cells as a Possible Target of Autoantibodies Contributing to Pregnancy Complications in Celiac Patients
por: Sóñora, C., et al.

NK cells restrain spontaneous antitumor CD8+ T cell priming through pd-1/pd-l1 interactions with dendritic cells
por: Raffo Iraolagoitia, X.L., et al.

Glycobiology of cell death: When glycans and lectins govern cell fate
Publicado: (2013)

Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference
por: Croci Russo, Diego Omar
Publicado: (2014)

Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference
por: Croci, D.O., et al.

Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors
por: Bae, G.-U., et al.

NK cells restrain spontaneous antitumor CD8+ T cell priming through pd-1/pd-l1 interactions with dendritic cells
por: Ziblat, Andrea, et al.
Publicado: (2016)

Tissue Transglutaminase on Trophoblast Cells as a Possible Target of Autoantibodies Contributing to Pregnancy Complications in Celiac Patients
Publicado: (2014)

Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors
Publicado: (2011)

Association of HO-1 and BRCA1 is critical for the maintenance of cellular homeostasis in prostate cancer
por: Gueron, Geraldine, et al.
Publicado: (2015)

Association of HO-1 and BRCA1 is critical for the maintenance of cellular homeostasis in prostate cancer
por: Labanca, E., et al.

Folding of a cyclin box: Linking multitarget binding to marginal stability, oligomerization, and aggregation of the retinoblastoma tumor suppressor ab pocket domain
Publicado: (2013)

Folding of a cyclin box: Linking multitarget binding to marginal stability, oligomerization, and aggregation of the retinoblastoma tumor suppressor ab pocket domain
por: Chemes, L.B., et al.

RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors
Publicado: (2016)

RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors
por: Wu, Y., et al.

RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells
Publicado: (2012)

RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells
por: Shan, B., et al.

Dok-4 is a novel negative regulator of T cell activation
Publicado: (2009)