Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons

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The proopiomelanocortin gene (POMC) is expressed in a group of neurons present in the arcuate nucleus of the hypothalamus. Neuron-specific POMC expression in mammals is conveyed by two distal enhancers, named nPE1 and nPE2. Previous transgenic mouse studies showed that nPE1 and nPE2 independently dr...

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Detalles Bibliográficos
Autores principales: Franchini, L.F., López-Leal, R., Nasif, S., Beati, P., Gelman, D.M., Low, M.J., De Souza, F.J.S., Rubinstein, M.
Formato: JOUR
Materias:
Obesity
Retroposition
Retrotransposition
Satiety
Shadow enhancer
enhanced green fluorescent protein
proopiomelanocortin
animal cell
animal experiment
arcuate nucleus
article
convergent evolution
diencephalon
evolutionary adaptation
fluorescence analysis
gene
gene expression
gene sequence
human
human cell
mammal
molecular evolution
mouse
nerve cell
nonhuman
nPE1 gene
nPE2 gene
placenta
placental mammals
priority journal
reporter gene
retroposon
tomato
transgenic mouse
vertebrate
Animals
Base Sequence
Enhancer Elements, Genetic
Evolution, Molecular
Female
Gene Expression Regulation, Developmental
Genes, Reporter
Humans
Mammals
Mice
Mice, Transgenic
Molecular Sequence Data
Neurons
Phylogeny
Placenta
Pregnancy
Pro-Opiomelanocortin
Retroelements
Time Factors
Eutheria
Lycopersicon esculentum
Mammalia
Mus musculus
Mya
Prototheria
Vertebrata
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00278424_v108_n37_p15270_Franchini
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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