Pathogen DNA as target for host-generated oxidative stress: Role for repair of bacterial DNA damage in Helicobacter pylori colonization

Helicobacter pylori elicits an oxidative stress during host colonization. This oxidative stress is known to cause lesions in the host DNA. Here we addressed the question as to whether the pathogen DNA is subject to lethal or mutational damage by the host-generated oxidative response. H. pylori Hpnth...

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Detalles Bibliográficos
Autores principales: O'Rourke, E.J., Chevalier, C., Pinto, A.V., Thiberge, J.M., Ielpi, L., Labigne, A., Radicella, J.P.
Formato: JOUR
Materias:
bacterial DNA
endonuclease
endonuclease iii
oxidizing agent
pyrimidine derivative
unclassified drug
adaptation
animal cell
animal experiment
animal model
article
bacterial colonization
bacterial genome
bacterial infection
bacterial mutation
bacterial strain
competitive ability
controlled study
DNA adduct
DNA damage
DNA repair
enzyme activity
enzyme deficiency
Helicobacter pylori
host pathogen interaction
macrophage activation
mouse
mutation rate
nonhuman
open reading frame
oxidative stress
polymerase chain reaction
priority journal
sequence analysis
stomach
Animals
Bacterial Proteins
DNA
DNA Damage
DNA Repair
Dose-Response Relationship, Drug
Drug Resistance
Genes, Bacterial
Genetic Complementation Test
Genotype
Hydrogen Peroxide
Macrophages
Mice
Mutation
Oxidative Stress
Oxygen
Phenotype
Plasmids
Rifampin
Sensitivity and Specificity
Stomach
Vitamin K 3
Animalia
Bacteria (microorganisms)
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00278424_v100_n5_p2789_ORourke
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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