Rabbit IgG antibodies against phospholipase A2 from Crotalus durissus terrificus neutralize the lethal activity of the venom

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Crotalus durissus terrificus (C.d.t.) (South American rattlesnake) venom possesses myotoxic and neurotoxic activities, both of which are also expressed by crotoxin, the principal toxin of this venom. Crotoxin contains a basic phospholipase A2 (PLA2) and a non toxic acidic protein, crotapotin. We hav...

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Detalles Bibliográficos
Autores principales: Rodriguez, J.P., De Marzi, M., Maruñak, S., Malchiodi, E.L., Leiva, L.C., Acosta, O.
Formato: JOUR
Lenguaje:English
Materias:
Antibodies IgG
Crotalus durissus terrificus
Neutralization
Phospholipase A2
crotoxin
Freund adjuvant
immunoglobulin G
phospholipase A2
snake venom
snake venom antiserum
animal experiment
animal model
article
controlled study
drug efficacy
envenomation
enzyme isolation
gel filtration chromatography
incubation time
inoculation
lethality
male
mortality
mouse
muscle disease
neurotoxicity
nonhuman
rabbit
snake
treatment outcome
Animals
Antibody Specificity
Antivenins
Buffers
Crotalus
Crotoxin
Hemolysis
Immunoglobulin G
Male
Mice
Neuromuscular Blockade
Neutralization Tests
Phospholipases A
Rabbits
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00257680_v66_n6_p512_Rodriguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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