Studies on the mechanism of the antiandrogenic effect of a putative 5α -reductase inhibitor

The mechanism of the antiandrogenic effect of 5,10-seco-19-norpregnane-4,5-diene-3,10,20-trione (secosteroid), reputedly an irreversible inhibitor of 5α -reductase, was investigated. Its addition (10 μM) to culture media effectively suppressed the synthesis of rat epididymal proteins specifically in...

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Detalles Bibliográficos
Autores principales: Vazquez, M.H., Tezon, J.G., Blaquier, J.A.
Formato: JOUR
Materias:
antiandrogen
enzyme inhibitor
steroid 5alpha reductase
animal cell
biological model
cell culture
endocrine system
epididymis
in vitro study
male genital system
nonhuman
rat
Androgen Antagonists
Animal
Binding, Competitive
Cytosol
Depression, Chemical
Epididymis
Gene Expression Regulation
Male
Microsomes
Norpregnadienes
Proteins
Rats
Rats, Inbred Strains
Receptors, Androgen
Stanolone
Support, Non-U.S. Gov't
Testosterone
Testosterone 5-alpha-Reductase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00224731_v28_n2_p227_Vazquez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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