Acoustic trauma slows AMPA receptor-mediated EPSCs in the auditory brainstem, reducing GluA4 subunit expression as a mechanism to rescue binaural function

Key points: Lateral superior olive (LSO) principal neurons receive AMPA receptor (AMPAR) - and NMDA receptor (NMDAR)-mediated EPSCs and glycinergic IPSCs. Both EPSCs and IPSCs have slow kinetics in prehearing animals, which during developmental maturation accelerate to sub-millisecond decay time-con...

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Detalles Bibliográficos
Autores principales: Pilati, N., Linley, D.M., Selvaskandan, H., Uchitel, O., Hennig, M.H., Kopp-Scheinpflug, C., Forsythe, I.D.
Formato: JOUR
Materias:
AMPA receptor
glutamate receptor 3
glutamate receptor 4
glycine receptor
glycine receptor alpha1
glycine receptor alpha2
messenger RNA
n methyl dextro aspartic acid receptor
receptor subunit
unclassified drug
adult
animal cell
animal experiment
animal model
animal tissue
Article
auditory brain stem
auditory system
auditory threshold
binaural hearing
brain stem
computer model
controlled study
correlation analysis
evoked brain stem auditory response
excitatory postsynaptic potential
female
in vivo study
inhibitory postsynaptic potential
male
mouse
noise injury
nonhuman
priority journal
protein expression
superior olivary nucleus
synapse
voltage clamp technique
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00223751_v594_n13_p3683_Pilati
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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