Isolation and structure elucidation of novel products of the acidic degradation of diazepam

The acidic degradation of diazepam in methanolic aqueous solution has been investigated. Apart from the known degradation products, 2‐(N‐methylamino)‐5‐chlorobenzophenone and glycine, produced by the hydrolytic cleavage of the benzodiazepinone ring, five novel products were isolated and fully charac...

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Detalles Bibliográficos
Autores principales: Nudelman, N.S., de Waisbaum, R.G.
Formato: JOUR
Materias:
5 chloro 2 (methylamino)benzophenone
benzophenone derivative
diazepam
glycine
unclassified drug
anxiety neurosis
article
controlled study
drug degradation
drug determination
drug hydrolysis
drug isolation
drug stability
drug structure
seizure
sleep disorder
withdrawal syndrome
Chromatography, Thin Layer
Diazepam
Drug Stability
Hydrolysis
Magnetic Resonance Spectroscopy
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Spectrum Analysis, Mass
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00223549_v84_n2_p208_Nudelman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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