Synthesis of multivalent glycoclusters from 1-thio-β-D-galactose and their inhibitory activity against the β-galactosidase from E. coli

The synthesis of multivalent glycoclusters, designed to be compatible with biological systems, is reported. A variety of 1-thio-β-d-galactosides linked to a terminal triple bond through oligoethyleneglycol chains of variable lengths has been synthesized. Also, azide-containing oligosaccharide scaffo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cagnoni, A.J., Varela, O., Gouin, S.G., Kovensky, J., Uhrig, M.L.
Formato:	JOUR
Materias:	Azidation Biological fluids CBr Click reaction D-galactose Deacetylation E. coli Galactosidases Inhibitory activity Maltotriose NMR spectroscopy Triple bonds Valencies Variable length Acetylation Biochemistry Carbohydrates Escherichia coli Microwave irradiation Nuclear magnetic resonance spectroscopy Oligosaccharides Scaffolds Synthesis (chemical) 1 thio beta dextro galactose azide beta galactosidase carbohydrate galactose macrogol maltose oligosaccharide thioglycoside trehalose unclassified drug antibacterial activity article bioavailability chemical bond cluster analysis deacetylation drug synthesis enzyme activity hydrophilicity microwave irradiation nonhuman nuclear magnetic resonance spectroscopy synthesis Alkynes Azides beta-Galactosidase Catalysis Copper Enzyme Inhibitors Galactose Galactosides Polyethylene Glycols Structure-Activity Relationship Thiosugars
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00223263_v76_n9_p3064_Cagnoni
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Synthesis of multivalent glycoclusters from 1-thio-β-D-galactose and their inhibitory activity against the β-galactosidase from E. coli
Publicado: (2011)

Synthesis of p-nitrophenyl β-d-galactofuranoside. A convenient substrate for β-galactofuranosidase
por: Varela, Oscar José, et al.
Publicado: (1986)

Synthesis of p-nitrophenyl β-d-galactofuranoside. A convenient substrate for β-galactofuranosidase
por: Varela, O., et al.

Escherichia coli β-galactosidase inhibitors through modifications at the aglyconic moiety: Experimental evidence of conformational distortion in the molecular recognition process
Publicado: (2013)

Escherichia coli β-galactosidase inhibitors through modifications at the aglyconic moiety: Experimental evidence of conformational distortion in the molecular recognition process
por: Calle, L., et al.

An improved microbial synthesis of purine nucleosides
Publicado: (2000)

An improved microbial synthesis of purine nucleosides
por: Lewkowicz, E.S., et al.

Synthesis of 4-nitrophenyl β-D-fucofuranoside and β-D-fucofuranosyl-(1 → 3)-D-mannopyranose: Modified substrates for studies on catalytic requirements of β-D-galactofuranosidase
Publicado: (1999)

Synthesis of 4-nitrophenyl β-D-fucofuranoside and β-D-fucofuranosyl-(1 → 3)-D-mannopyranose: Modified substrates for studies on catalytic requirements of β-D-galactofuranosidase
por: Chiocconi, A., et al.

Synthesis and characterization of some nitrogen heterocycles from D- galactose derivatives
por: D'Accorso, Norma Beatriz
Publicado: (1999)

Synthesis and characterization of some nitrogen heterocycles from D- galactose derivatives
por: Faraco, A.A.G., et al.

Specific tritium labeling of β-D-galactofuranosides at the 6-position: A tool for β-D-galactofuranosidase detection
Publicado: (2002)

Specific tritium labeling of β-D-galactofuranosides at the 6-position: A tool for β-D-galactofuranosidase detection
por: Mariño, K., et al.

Unusual stability and translation kinetics of an Escherichia coli lac messenger RNA synthetized during amino-acids deprivation
Publicado: (1977)

Unusual stability and translation kinetics of an Escherichia coli lac messenger RNA synthetized during amino-acids deprivation
por: de Rivas, C.S., et al.

An electrochemiluminescent method for the detection of β-lactamases in microorganisms
por: Priano, Graciela Inés, et al.
Publicado: (2001)

An electrochemiluminescent method for the detection of β-lactamases in microorganisms
por: Priano, G., et al.

Putrescine distribution in Escherichia coli studied in vivo by 13C nuclear magnetic resonance
por: Frydman, Benjamín Jaime, et al.
Publicado: (1984)

Putrescine distribution in Escherichia coli studied in vivo by 13C nuclear magnetic resonance
por: Frydman, B., et al.

β-galactosidase activity as affected by apparent pH and physical properties of reduced moisture systems
por: Burín, Leila, et al.
Publicado: (2002)

β-galactosidase activity as affected by apparent pH and physical properties of reduced moisture systems
por: Burin, L., et al.

Inactivation of Escherichia coli by a combination of nisin, pulsed electric fields, and water activity reduction by sodium chloride
por: Terebiznik, Mauricio R., et al.
Publicado: (2002)

Inactivation of Escherichia coli by a combination of nisin, pulsed electric fields, and water activity reduction by sodium chloride
por: Terebiznik, M., et al.

In vitro bactericidal activity of honey against Escherichia coli and Staphylococcus aureus. Comparison with the activity of cephalosporins
por: DELL'ELCE, Antonella, et al.
Publicado: (2018)

The formation of an unsaturated lactone derivative on benzoylation of D-galactonolactone
por: Muchnik de Lederkremer, Rosa María, et al.
Publicado: (1971)

The formation of an unsaturated lactone derivative on benzoylation of D-galactonolactone
por: De Lederkremer, R.M., et al.

Synthesis and characterization of two 1,2,3,6,2′,3′,4′,6′-octa-O-benzoyl-β-d-hexapyranosyl-(1 → 4)β-d-allopyranoses
por: D'Accorso, Norma Beatriz, et al.
Publicado: (1993)

Synthesis and characterization of two 1,2,3,6,2′,3′,4′,6′-octa-O-benzoyl-β-d-hexapyranosyl-(1 → 4)β-d-allopyranoses
por: D'Accorso, N.B., et al.

Synthesis of the (1→6)-linked thiodisaccharide of galactofuranose: Inhibitory activity against a β-galactofuranosidase
Publicado: (2013)

Synthesis of the (1→6)-linked thiodisaccharide of galactofuranose: Inhibitory activity against a β-galactofuranosidase
por: Repetto, E., et al.

Propuesta de una dosis de marbofloxacina para el tratamiento de infecciones asociadas a Escherichia coli en cabras de tres semanas de vida
por: DELL'ELCE, Antonella, et al.
Publicado: (2019)

On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate
por: De Robertis, Eduardo M.F., et al.
Publicado: (1973)

On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate
por: De Robertis Jr., E.M., et al.

Evaluación de la persistencia y patgenicidad de cepas de Escherichia coli productora de toxina shiga y Escherichia coli enteropatógena en arena
por: Sanin, Mariana, et al.
Publicado: (2020)

Catabolite translational effects on the lac messenger RNA of Escherichia coli K12
Publicado: (1976)

Catabolite translational effects on the lac messenger RNA of Escherichia coli K12
por: Sanchez de Rivas, C., et al.

Effect of hydrogen peroxide concentration and pH on inactivation kinetics of Escherichia coli
por: Raffellini, Silvia Mónica, et al.
Publicado: (2008)

Effect of hydrogen peroxide concentration and pH on inactivation kinetics of Escherichia coli
por: Raffellini, S., et al.

Influence of exo β-D-galactofuranosidase inhibitors in cultures of Penicillium fellutanum and modifications in hyphal cell structure
Publicado: (2002)

Influence of exo β-D-galactofuranosidase inhibitors in cultures of Penicillium fellutanum and modifications in hyphal cell structure
por: Mariño, K., et al.