Oxidative cyclization of iodo ketones. Synthesis of 6-oxa-5α-pregnane-3,20-dione
The steroidal δ- and γ-iodo ketones 1 and 9 were converted to the cyclic hemiketals 3 and 10, by oxidation to the iodoso derivatives with m-CPBA. Spontaneous cyclization of the latter intermediates to the corresponding oxocarbenium ions, followed by stereoselective addition of water, rendered the he...
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| Autores principales: | Nicoletti, D., Ghini, A.A., Burton, G. |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00223263_v61_n19_p6673_Nicoletti |
| Aporte de: |
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