Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells

Pregabalin (PGB) is extensively prescribed to treat neurological and neuropsychiatrical conditions such as neuropathic pain, anxiety disorders, and epilepsy. Although PGB is known to bind selectively to the α2δ subunit of voltage-gated calcium channels, there is little understanding about how it exe...

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Detalles Bibliográficos
Autores principales: Lempel, A.A., Coll, L., Schinder, A.F., Uchitel, O.D., Piriz, J.
Formato: JOUR
Materias:
dentate gyrus
Gabapentin
neurogenesis
Pregabalin
pregabalin
retrovirus vector
4 aminobutyric acid
calcium channel
adult
animal cell
animal experiment
animal tissue
Article
brain electrophysiology
brain function
cell maturation
controlled study
dentate hilus
drug mechanism
ex vivo study
excitatory postsynaptic potential
granule cell
in vivo study
male
mouse
nerve cell excitability
nerve cell plasticity
neuroanatomy
neuromodulation
newborn
nonhuman
priority journal
synaptic transmission
whole cell patch clamp
aging
animal
C57BL mouse
cell granule
drug effects
epilepsy
metabolism
nerve cell
neuralgia
physiology
Aging
Animals
Calcium Channels
Cytoplasmic Granules
Dentate Gyrus
Epilepsy
gamma-Aminobutyric Acid
Mice, Inbred C57BL
Neuralgia
Neurons
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00223042_v140_n2_p257_Lempel
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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