Amyotrophic lateral sclerosis-immunoglobulins selectively interact with neuromuscular junctions expressing P/Q-type calcium channels

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a gradual loss of motoneurons. The majority of ALS cases are associated with a sporadic form whose etiology is unknown. Several pieces of evidence favor autoimmunity as a potential contributor to sporadic ALS p...

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Detalles Bibliográficos
Autores principales: Gonzalez, L.E., Kotler, M.L., Vattino, L.G., Conti, E., Reisin, R.C., Mulatz, K.J., Snutch, T.P., Uchitel, O.D.
Formato: JOUR
Materias:
amyotrophic lateral sclerosis
autoantibodies
autoimmunity
calcium channels
autoantibody
calcium channel P type
calcium channel Q type
immunoglobulin G
voltage gated calcium channel
acetylcholine release
adult
aged
animal cell
animal experiment
antibody labeling
article
cerebellum
clinical article
controlled study
down regulation
embryo
endplate potential
female
human
human cell
immunofluorescence
immunoreactivity
male
motoneuron
mouse
neuromuscular synapse
nonhuman
priority journal
protein expression
protein protein interaction
signal transduction
spinal cord
synaptic potential
Aged
Amyotrophic Lateral Sclerosis
Analysis of Variance
Animals
Animals, Newborn
Bungarotoxins
Calcium Channels, N-Type
Cell Line, Transformed
Central Nervous System
Diaphragm
Female
Humans
Immunoglobulin G
Immunoprecipitation
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Middle Aged
Miniature Postsynaptic Potentials
Neuromuscular Junction
Synaptophysin
Transfection
Vesicle-Associated Membrane Protein 2
Mus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00223042_v119_n4_p826_Gonzalez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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