Structural model for p75 NTR-TrkA intracellular domain interaction: A combined FRET and bioinformatics study

Nerve growth factor (NGF) is a member of the neurotrophins, which are important regulators of embryonic development and adult function in the vertebrate nervous systems. The signaling elicited by NGF regulates diverse activities, including survival, axon growth, and synaptic plasticity. NGF action i...

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Detalles Bibliográficos
Autores principales: Iacaruso, M.F., Galli, S., Martí, M., Villalta, J.I., Estrin, D.A., Jares-Erijman, E.A., Pietrasanta, L.I.
Formato: JOUR
Materias:
heterodimerization
molecular dynamics
NGF receptors
physical association
structural model
adaptor protein
nerve growth factor
nerve growth factor receptor
neurotrophin receptor p75
protein tyrosine kinase A
animal cell
article
binding site
bioinformatics
cell membrane
complex formation
controlled study
dimerization
fluorescence resonance energy transfer
nonhuman
nuclear magnetic resonance spectroscopy
priority journal
protein domain
protein protein interaction
protein structure
signal transduction
Animals
Computational Biology
Fluorescence Resonance Energy Transfer
Hippocampus
Mice
Nerve Growth Factor
PC12 Cells
Protein Binding
Protein Interaction Domains and Motifs
Rats
Receptor, Nerve Growth Factor
Receptor, trkA
Structural Homology, Protein
Vertebrata
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00222836_v414_n5_p681_Iacaruso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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