Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis

As a part of our project aimed at the search for new safe chemotherapeutic and chemoprophylactic agents against American trypanosomiasis (Chagas's disease); a series of phosphinopeptides structurally related to glutathione was designed, synthesized, and evaluated as antiproliferative agents aga...

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Detalles Bibliográficos
Autores principales: Ravaschino, E.L., Docampo, R., Rodriguez, J.B.
Formato: JOUR
Materias:
1 butyl [[(gamma glutamylleucyl)amino]methyl]phosphinate
1 pentyl [[(gamma glutamylleucyl)amino]methyl]phosphinate
phosphinic acid derivative
trypanothione
unclassified drug
amastigote
antiprotozoal activity
article
Chagas disease
drug design
drug efficacy
drug structure
drug synthesis
myoblast
pharmacophore
Trypanosoma cruzi
Amide Synthases
Animals
Antiprotozoal Agents
Cell Proliferation
Drug Design
Glutathione
Molecular Structure
Parasitic Sensitivity Tests
Peptides
Phenyl Ethers
Phosphinic Acids
Spermidine
Structure-Activity Relationship
Thiocyanates
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00222623_v49_n1_p426_Ravaschino
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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