Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft

Chemokines such as monocyte chemoattractant protein (MCP)-1 are key agonists that attract macrophages to tumors. In melanoma, it has been previously shown that variable levels of MCP-1/CCL2 appear to correlate with infiltrating macrophages and tumor fate, with low to intermediate levels of the chemo...

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Detalles Bibliográficos
Autores principales: Gazzaniga, S., Bravo, A.I., Guglielmotti, A., Van Rooijen, N., Maschi, F., Vecchi, A., Mantovani, A., Mordoh, J., Wainstok, R.
Formato: JOUR
Materias:
2 methyl 2 [(1 (phenylmethyl) 1h indazol 3yl)methoxy]propanoic acid
clodronic acid
monocyte chemotactic protein 1
propionic acid derivative
unclassified drug
animal cell
animal experiment
animal model
animal tissue
article
cancer inhibition
controlled study
expression vector
genetic transfection
human
human cell
melanoma
mouse
nonhuman
priority journal
tumor associated leukocyte
tumor growth
tumor necrosis
tumor vascularization
xenograft
Animals
Antigens, CD31
Cell Line, Tumor
Chemokine CCL2
Clodronic Acid
Humans
Indazoles
Liposomes
Macrophages
Male
Melanoma, Experimental
Mice
Neoplasm Transplantation
Neovascularization, Pathologic
Propionic Acids
Transplantation, Heterologous
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0022202X_v127_n8_p2031_Gazzaniga
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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