The role of N-β-alanyldopamine synthase in the innate immune response of two insects

Insects trigger a multifaceted innate immune response to fight microbial infections. We show that in the yellow mealworm, Tenebrio molitor, septic injuries induce the synthesis of N-β-alanyldopamine (NBAD), which is known as the main sclerotization precursor of insect brown cuticles. We demonstrate...

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Autores principales:	Schachter, J., Pérez, M.M., Quesada-Allué, L.A.
Formato:	JOUR
Materias:	β-alanine Ceratitis capitata Insect immunity N-β-alanyldopamine Tenebrio molitor catecholamine beta alanyl ligase catecholamine-beta-alanyl ligase dopamine drug derivative insect protein ligase N(beta) alanyldopamine N(beta)-alanyldopamine unclassified drug beetle enzyme activity fly immune response larva animal article enzyme induction enzymology epidermis Escherichia coli immunology innate immunity Mediterranean fruit fly metabolism microbiology physiology Tenebrio time Animals Dopamine Enzyme Induction Epidermis Immunity, Natural Insect Proteins Larva Ligases Time Factors Hexapoda
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00221910_v53_n11_p1188_Schachter
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00221910_v53_n11_p1188_Schachter2023-10-03T14:28:16Z The role of N-β-alanyldopamine synthase in the innate immune response of two insects Schachter, J. Pérez, M.M. Quesada-Allué, L.A. β-alanine Ceratitis capitata Insect immunity N-β-alanyldopamine Tenebrio molitor catecholamine beta alanyl ligase catecholamine-beta-alanyl ligase dopamine drug derivative insect protein ligase N(beta) alanyldopamine N(beta)-alanyldopamine unclassified drug beetle enzyme activity fly immune response larva animal article enzyme induction enzymology epidermis Escherichia coli immunology innate immunity larva Mediterranean fruit fly metabolism microbiology physiology Tenebrio time Animals Ceratitis capitata Dopamine Enzyme Induction Epidermis Escherichia coli Immunity, Natural Insect Proteins Larva Ligases Tenebrio Time Factors Ceratitis capitata Escherichia coli Hexapoda Tenebrio Tenebrio molitor Insects trigger a multifaceted innate immune response to fight microbial infections. We show that in the yellow mealworm, Tenebrio molitor, septic injuries induce the synthesis of N-β-alanyldopamine (NBAD), which is known as the main sclerotization precursor of insect brown cuticles. We demonstrate that NBAD synthase is induced in the epidermis of the mealworm and of the Medfly, Ceratitis capitata, by infection with Escherichia coli. Our results indicate that synthesis of NBAD seems to be a novel component of the overall innate immune response in insects. © 2007 Elsevier Ltd. All rights reserved. Fil:Pérez, M.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Quesada-Allué, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00221910_v53_n11_p1188_Schachter
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	β-alanine Ceratitis capitata Insect immunity N-β-alanyldopamine Tenebrio molitor catecholamine beta alanyl ligase catecholamine-beta-alanyl ligase dopamine drug derivative insect protein ligase N(beta) alanyldopamine N(beta)-alanyldopamine unclassified drug beetle enzyme activity fly immune response larva animal article enzyme induction enzymology epidermis Escherichia coli immunology innate immunity larva Mediterranean fruit fly metabolism microbiology physiology Tenebrio time Animals Ceratitis capitata Dopamine Enzyme Induction Epidermis Escherichia coli Immunity, Natural Insect Proteins Larva Ligases Tenebrio Time Factors Ceratitis capitata Escherichia coli Hexapoda Tenebrio Tenebrio molitor
spellingShingle	β-alanine Ceratitis capitata Insect immunity N-β-alanyldopamine Tenebrio molitor catecholamine beta alanyl ligase catecholamine-beta-alanyl ligase dopamine drug derivative insect protein ligase N(beta) alanyldopamine N(beta)-alanyldopamine unclassified drug beetle enzyme activity fly immune response larva animal article enzyme induction enzymology epidermis Escherichia coli immunology innate immunity larva Mediterranean fruit fly metabolism microbiology physiology Tenebrio time Animals Ceratitis capitata Dopamine Enzyme Induction Epidermis Escherichia coli Immunity, Natural Insect Proteins Larva Ligases Tenebrio Time Factors Ceratitis capitata Escherichia coli Hexapoda Tenebrio Tenebrio molitor Schachter, J. Pérez, M.M. Quesada-Allué, L.A. The role of N-β-alanyldopamine synthase in the innate immune response of two insects
topic_facet	β-alanine Ceratitis capitata Insect immunity N-β-alanyldopamine Tenebrio molitor catecholamine beta alanyl ligase catecholamine-beta-alanyl ligase dopamine drug derivative insect protein ligase N(beta) alanyldopamine N(beta)-alanyldopamine unclassified drug beetle enzyme activity fly immune response larva animal article enzyme induction enzymology epidermis Escherichia coli immunology innate immunity larva Mediterranean fruit fly metabolism microbiology physiology Tenebrio time Animals Ceratitis capitata Dopamine Enzyme Induction Epidermis Escherichia coli Immunity, Natural Insect Proteins Larva Ligases Tenebrio Time Factors Ceratitis capitata Escherichia coli Hexapoda Tenebrio Tenebrio molitor
description	Insects trigger a multifaceted innate immune response to fight microbial infections. We show that in the yellow mealworm, Tenebrio molitor, septic injuries induce the synthesis of N-β-alanyldopamine (NBAD), which is known as the main sclerotization precursor of insect brown cuticles. We demonstrate that NBAD synthase is induced in the epidermis of the mealworm and of the Medfly, Ceratitis capitata, by infection with Escherichia coli. Our results indicate that synthesis of NBAD seems to be a novel component of the overall innate immune response in insects. © 2007 Elsevier Ltd. All rights reserved.
format	JOUR
author	Schachter, J. Pérez, M.M. Quesada-Allué, L.A.
author_facet	Schachter, J. Pérez, M.M. Quesada-Allué, L.A.
author_sort	Schachter, J.
title	The role of N-β-alanyldopamine synthase in the innate immune response of two insects
title_short	The role of N-β-alanyldopamine synthase in the innate immune response of two insects
title_full	The role of N-β-alanyldopamine synthase in the innate immune response of two insects
title_fullStr	The role of N-β-alanyldopamine synthase in the innate immune response of two insects
title_full_unstemmed	The role of N-β-alanyldopamine synthase in the innate immune response of two insects
title_sort	role of n-β-alanyldopamine synthase in the innate immune response of two insects
url	http://hdl.handle.net/20.500.12110/paper_00221910_v53_n11_p1188_Schachter
work_keys_str_mv	AT schachterj theroleofnbalanyldopaminesynthaseintheinnateimmuneresponseoftwoinsects AT perezmm theroleofnbalanyldopaminesynthaseintheinnateimmuneresponseoftwoinsects AT quesadaalluela theroleofnbalanyldopaminesynthaseintheinnateimmuneresponseoftwoinsects AT schachterj roleofnbalanyldopaminesynthaseintheinnateimmuneresponseoftwoinsects AT perezmm roleofnbalanyldopaminesynthaseintheinnateimmuneresponseoftwoinsects AT quesadaalluela roleofnbalanyldopaminesynthaseintheinnateimmuneresponseoftwoinsects
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The role of N-β-alanyldopamine synthase in the innate immune response of two insects

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