Suppression of autoimmune diabetes by soluble galectin-1

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that targets the β-cells of the pancreas. We investigated the ability of soluble galectin-1 (gal-1), an endogenous lectin that promotes T cell apoptosis, to down-regulate the T cell response that destroys the pancreatic β-cells. We demons...

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Detalles Bibliográficos
Autores principales: Perone, M.J., Bertera, S., Shufesky, W.J., Divito, S.J., Montecalvo, A., Mathers, A.R., Larregina, A.T., Pang, M., Seth, N., Wucherpfennig, K.W., Trucco, M., Baum, L.G., Morelli, A.E.
Formato: JOUR
Materias:
galectin 1
interleukin 10
interleukin 4
interleukin 5
antidiabetic agent
animal cell
animal experiment
animal model
animal tissue
article
autoimmune disease
CD4+ T lymphocyte
controlled study
diabetes mellitus
down regulation
helper cell
hyperglycemia
insulitis
mouse
nonhuman
priority journal
regulatory T lymphocyte
T lymphocyte
animal
Bagg albino mouse
female
human
immunology
insulin dependent diabetes mellitus
intraperitoneal drug administration
metabolism
mouse mutant
nonobese diabetic mouse
pancreas islet beta cell
pathology
physiology
transgenic mouse
Animals
Autoimmune Diseases
Diabetes Mellitus, Type 1
Female
Galectin 1
Humans
Hypoglycemic Agents
Injections, Intraperitoneal
Insulin-Secreting Cells
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
Mice, SCID
Mice, Transgenic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00221767_v182_n5_p2641_Perone
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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