Dok-4 is a novel negative regulator of T cell activation

Dok-4 (downstream of tyrosine kinase-4) is a recently identified member of the Dok family of adaptor proteins, which are characterized by an amino-terminal pleckstrin homology domain, a phosphotyrosine-binding domain, and a carboxyl-terminal region containing several tyrosines and poly-proline-rich...

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Detalles Bibliográficos
Autores principales: Gérard, A., Ghiotto, M., Fos, C., Guittard, G., Compagno, D., Galy, A., Lemay, S., Olive, D., Nunès, J.A.
Formato: JOUR
Materias:
downstream of tyrosine kinase 4
interleukin 2
mitogen activated protein kinase
pleckstrin
Rap1 protein
regulator protein
RNA
T lymphocyte receptor
unclassified drug
DOK4 protein, human
lymphocyte antigen receptor
phosphotyrosine
signal peptide
article
controlled study
cytoplasm
human
human cell
immunological synapse
loss of function mutation
lymphocyte proliferation
microtubule
polarization
priority journal
promoter region
protein domain
protein localization
protein phosphorylation
RNA interference
T lymphocyte activation
wild type
antigen presenting cell
cell communication
cell line
chemistry
gene expression regulation
genetics
immunology
lymphocyte activation
metabolism
microtubule organizing center
protein motif
signal transduction
T lymphocyte
Amino Acid Motifs
Antigen-Presenting Cells
Cell Communication
Cell Line
Gene Expression Regulation
Humans
Intracellular Signaling Peptides and Proteins
Lymphocyte Activation
Microtubule-Organizing Center
Phosphotyrosine
Promoter Regions, Genetic
Receptors, Antigen, T-Cell
Signal Transduction
T-Lymphocytes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00221767_v182_n12_p7681_Gerard
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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