Synthesis and NMR analysis of spiranic heterocycles from carbohydrate derivatives

(Chemical Equation Presented) We report the synthesis of some furanose and pyranose acylhydrazones and their heterocyclization products. The new compounds were characterized physically and spectroscopically and the syn-anti and (R)-(S) configuration was determined by NOESY experiments. We discuss th...

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Detalles Bibliográficos
Autores principales: Martins Alho, M.A., D'Accorso, N.B.
Formato: JOUR
Materias:
carbohydrate derivative
furanose acylhydrazone
heterocyclic compound
hydrazone derivative
pyranose acylhydrazone
unclassified drug
article
carbon nuclear magnetic resonance
chemical structure
cyclization
nuclear Overhauser effect
proton nuclear magnetic resonance
reaction analysis
synthesis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0022152X_v44_n4_p901_MartinsAlho
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:(Chemical Equation Presented) We report the synthesis of some furanose and pyranose acylhydrazones and their heterocyclization products. The new compounds were characterized physically and spectroscopically and the syn-anti and (R)-(S) configuration was determined by NOESY experiments. We discuss the influence of the nucleophile, the temperature and the precursor structure on the heterocyclization products.

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