Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells

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If irradiated tumor cells could be rendered immunogenic, they would provide a safe, broad, and patient-specific array of antigens for immunotherapies. Prior approaches have emphasized genetic transduction of live tumor cells to express cytokines, costimulators, and surrogate foreign antigens. We ask...

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Detalles Bibliográficos
Autores principales: Liu, K., Idoyaga, J., Charalambous, A., Fujii, S.-I., Bonito, A., Mordoh, J., Wainstok, R., Bai, X.-F., Liu, Y., Steinman, R.M.
Formato: JOUR
Materias:
adjuvant
alpha CD40 antibody
alpha galactosylceramide
antibody
CD4 antigen
CD8 antigen
glycolipid
major histocompatibility antigen class 1
polyinosinic polycytidylic acid
tumor antigen
unclassified drug
animal cell
animal experiment
animal model
article
cell differentiation
cell maturation
controlled study
dendritic cell
drug delivery system
drug uptake
female
irradiation
lymph node
lymphoid organ
lymphoma
major histocompatibility complex
mouse
natural killer cell
nonhuman
plasmacytoma
priority journal
spleen
spleen cell
T lymphocyte
tumor immunity
tumor resistance
vaccination
Adjuvants, Immunologic
Animals
Antigen Presentation
Antigens, Neoplasm
Cancer Vaccines
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Differentiation
Dendritic Cells
Female
Gamma Rays
Immunotherapy, Active
Killer Cells, Natural
Lymph Nodes
Lymphocyte Activation
Lymphoma
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neoplasms, Experimental
Plasmacytoma
Spleen
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00221007_v202_n11_p1507_Liu
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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