Glucocorticoid alternative effects on proliferating and differentiated mammary epithelium are associated to opposite regulation of cell-cycle inhibitor expression

Glucocorticoids influence post-natal mammary gland development by sequentially controlling cell proliferation, differentiation, and apoptosis. In the mammary gland, it has been demonstrated that glucocorticoid treatment inhibits epithelial apoptosis in post-lactating glands. In this study, our first...

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Detalles Bibliográficos
Autores principales: Hoijman, E., Rocha-Viegas, L., Kalko, S.G., Rubinstein, N., Morales-Ruiz, M., de Kier Joffé, E.B., Kordon, E.C., Pecci, A.
Formato: JOUR
Materias:
ATM protein
caspase 3
CRADD protein
cyclin dependent kinase inhibitor 1
cyclin dependent kinase inhibitor 2C
dexamethasone
animal cell
animal experiment
animal tissue
apoptosis
article
breast epithelium
cell cycle regulation
cell differentiation
cell proliferation
cell survival
controlled study
down regulation
female
gene expression
gene expression profiling
gene overexpression
lactation
mammary gland
microarray analysis
mouse
nonhuman
nucleotide sequence
priority journal
regulatory mechanism
Animals
Cell Cycle
Cell Cycle Proteins
Cell Differentiation
Cell Proliferation
Cyclin-Dependent Kinase Inhibitor p18
Cyclin-Dependent Kinase Inhibitor p21
Dexamethasone
DNA-Binding Proteins
Epithelial Cells
Female
Gene Expression Regulation, Developmental
Glucocorticoids
Lactation
Mammary Glands, Animal
Mice
Mice, Inbred BALB C
Protein-Serine-Threonine Kinases
Tumor Suppressor Proteins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219541_v227_n4_p1721_Hoijman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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