Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation

Glucocorticoids play an important role in adipogenesis through the glucocorticoid receptor (GR) that forms a heterocomplex with Hsp90NHsp70 and one high molecular weight immunophilin, either FKBP51 or FKBP52. When 3T3-L1 preadipocytes are induced to differentiate, FKBP51 expression progressively inc...

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Detalles Bibliográficos
Autores principales:	Toneatto, J., Guber, S., Charó, N.L., Susperreguy, S., Schwartz, J., Galigniana, M.D., Piwien-Pilipuk, G.
Formato:	JOUR
Materias:	Adipogenesis FKBP51 Glucocorticoid receptor PKA bucladesine cyclic AMP dependent protein kinase fkbp51 protein forskolin glucocorticoid receptor immunophilin isobutylmethylxanthine lamin B protein kinase a c alpha small interfering RNA unclassified drug adipocyte adipogenesis animal cell article cell differentiation cell nucleus matrix cellular distribution chromatin controlled study electrophoretic mobility enzyme inhibition enzyme substrate gene expression regulation gene silencing human human cell intracellular signaling mitochondrion mouse nonhuman nuclear lamina priority journal proadipocyte protein localization protein protein interaction protein transport transcription regulation 1-Methyl-3-isobutylxanthine 3T3-L1 Cells Animals Cell Differentiation Cell Nucleus Chromatin Colforsin Cyclic AMP-Dependent Protein Kinases Gene Expression Regulation HSP70 Heat-Shock Proteins HSP90 Heat-Shock Proteins Mice Mitochondria Peptides Protein Binding Protein Kinase C-alpha Protein Kinase Inhibitors Protein Transport Receptors, Glucocorticoid RNA, Small Interfering Signal Transduction Tacrolimus Binding Proteins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00219533_v126_n23_p5357_Toneatto
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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