The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-α /Sima

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The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor composed of a constitutively expressed HIF-β subunit and an oxygen-regulated HIF-α subunit. We have previously defined a hypoxia-inducible transcriptional response in Drosophila melanogaster that is homologous to the mammalia...

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Detalles Bibliográficos
Autores principales:	Dekanty, A., Lavista-Llanos, S., Irisarri, M., Oldham, S., Wappner, P.
Formato:	JOUR
Materias:	Drosphila Hypoxia-inducible factor (HIF) Nuclear localization PI3K pathway Sima hypoxia inducible factor 1alpha hypoxia inducible factor 1beta insulin messenger RNA phosphatidylinositol 3 kinase phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase B protein similar protein tango transcription factor transcription factor PAS unclassified drug article cellular distribution Drosophila embryo embryo development enzyme activation gene overexpression immunofluorescence in vivo study nonhuman Northern blotting polyacrylamide gel electrophoresis priority journal protein localization protein stability reverse transcription polymerase chain reaction RNA interference signal transduction transcription regulation upregulation 1-Phosphatidylinositol 3-Kinase Active Transport, Cell Nucleus Animals Aryl Hydrocarbon Receptor Nuclear Translocator Cell Hypoxia Cell Line Cell Nucleus DNA-Binding Proteins Dose-Response Relationship, Drug Drosophila Proteins Embryo, Nonmammalian Gene Expression Regulation Hypoxia-Inducible Factor 1, alpha Subunit Insulin Oxygen Proto-Oncogene Proteins c-akt RNA RNA Interference Signal Transduction Transcription, Genetic Drosophila melanogaster Mammalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00219533_v118_n23_p5431_Dekanty
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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