DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation

Heterogeneous nuclear ribonucleoprotein (hnRNP) K is a nucleocytoplasmic shuttling protein that is a key player in the p53-triggered DNA damage response, acting as a cofactor for p53 in response to DNA damage. hnRNP K is a substrate of the ubiquitin E3 ligase MDM2 and, upon DNA damage, is de-ubiquit...

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Detalles Bibliográficos
Autores principales: Pelisch, F., Pozzi, B., Risso, G., Muñoz, M.J., Srebrow, A.
Formato: JOUR
Materias:
Co-activation
Cofactors
DNA damage response
DNA damages
E3 ligase
Heterogeneous nuclear ribonucleoprotein (hnRNP)
Nuclear ribonucleoprotein
Nucleo-cytoplasmic shuttling
Post-translational modifications
Sharp contrast
SUMO conjugation
Sumoylation
Target genes
Transcriptional activations
Ubiquitin
Amino acids
Genes
DNA
heterogeneous nuclear ribonucleoprotein K
lysine
polycomb group protein
protein p53
SUMO protein
ubiquitin protein ligase E3
article
carboxy terminal sequence
controlled study
DNA damage
enzyme activation
enzyme activity
gene
gene expression regulation
gene targeting
human
human cell
p21 gene
priority journal
protein domain
protein function
signal transduction
sumoylation
transcription initiation
transcription regulation
tumor suppressor gene
ubiquitination
Cell Line, Tumor
DNA Damage
HEK293 Cells
Humans
Polycomb-Group Proteins
Proto-Oncogene Proteins c-mdm2
Ribonucleoproteins
SUMO-1 Protein
Transcriptional Activation
Tumor Suppressor Protein p53
Ubiquitin-Protein Ligases
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v287_n36_p30789_Pelisch
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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