Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein

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Accurate characterization of the molecular mechanisms of the action of ligands is an extremely important issue for their appropriate research, pharmacological, and therapeutic uses. In view of this fact, the aim of the present work was to investigate the mechanisms involved in the actions of mepyram...

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Detalles Bibliográficos
Autores principales:	Fitzsimons, C.P., Monczor, F., Fernández, N., Shayo, C., Davio, C.
Formato:	JOUR
Materias:	Adenosinetriphosphate Biochemistry Calcium Cells Proteins Mepyramine Molecular mechanisms Pharmacology Signaling pathways Drug products calcium G protein coupled receptor histamine H1 receptor mepyramine purine receptor adenosine triphosphate guanine nucleotide binding protein guanine nucleotide binding protein alpha subunit guanosine 5' o (3 thiotriphosphate) histamine H1 receptor antagonist inositol phosphate ligand triprolidine animal cell article calcium blood level Chinese hamster CHO cell controlled study drug mechanism guinea pig molecular model nonhuman nucleotide sequence priority journal protein expression receptor affinity signal transduction animal cell membrane chemical model chemistry dose response hamster metabolism molecular cloning protein binding Western blotting Animalia Cavia porcellus Cricetinae Cricetulus griseus Sus scrofa Adenosine Triphosphate Animals Blotting, Western Cell Membrane CHO Cells Cloning, Molecular Dose-Response Relationship, Drug GTP-Binding Protein alpha Subunits, Gq-G11 GTP-Binding Proteins Guanosine 5'-O-(3-Thiotriphosphate) Guinea Pigs Histamine H1 Antagonists Inositol Phosphates Ligands Models, Chemical Protein Binding Pyrilamine Receptors, Histamine H1 Triprolidine
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00219258_v279_n33_p34431_Fitzsimons
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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