Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells

The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA s...

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Detalles Bibliográficos
Autores principales: Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G., Tesone, M.
Formato: JOUR
Materias:
iturelix
leuprorelin
apoptosis
article
cell proliferation
DNA synthesis
drug antagonism
drug effect
granulosa cell
human
human cell
priority journal
Apoptosis
Cell Proliferation
Female
Gonadotropin-Releasing Hormone
Granulosa Cells
Humans
Leuprolide
Oligopeptides
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00150282_v85_n4_p1064_Vitale
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA synthesis on basal conditions. Leuprolide acetate produced an increase in the percentage of apoptotic cells, and when these two factors were co-incubated, ANT blocked the apoptotic effect produced by LA. ©2006 by American Society for Reproductive Medicine.

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