Trypanosoma cruzi: In vitro and in vivo antiproliferative effects of epigallocatechin gallate (EGCg)

The trypanocidal activity of catechins on Trypanosoma cruzi bloodstream trypomastigotes has been previously reported. Herein, we present the effect of epigallocatechin gallate (EGCg) on parasitemia and survival in a murine model of acute Chagas' disease as well as on the epimastigote form of th...

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Detalles Bibliográficos
Autores principales: Güida, M.C., Esteva, M.I., Camino, A., Flawiá, M.M., Torres, H.N., Paveto, C.
Formato: JOUR
Materias:
Epigallocatechin gallate
PCD
Programmed cell death
Trypanocide Chagas' disease
epigallocatechin gallate
animal experiment
animal model
animal tissue
apoptosis
article
Chagas disease
controlled study
drug mechanism
fragmentation reaction
growth inhibition
histopathology
in vitro study
in vivo study
male
mouse
nonhuman
parasitemia
priority journal
survival rate
Trypanosoma cruzi
trypomastigote
Animals
Antioxidants
Catechin
Chagas Disease
Disease Models, Animal
DNA Fragmentation
Dose-Response Relationship, Drug
Hepatocytes
In Situ Nick-End Labeling
Male
Mice
Mice, Inbred BALB C
Parasitemia
Random Allocation
Trypanocidal Agents
Animalia
Murinae
Mus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144894_v117_n2_p188_Guida
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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