Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth

Axonal growth cone collapse following spinal cord injury (SCI) is promoted by semaphorin3A (Sema3A) signaling via PlexinA4 surface receptor. This interaction triggers intracellular signaling events leading to increased hydrogen peroxide levels which in turn promote filamentous actin (F-actin) destab...

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Detalles Bibliográficos
Autores principales: Quintá, H.R., Wilson, C., Blidner, A.G., González-Billault, C., Pasquini, L.A., Rabinovich, G.A., Pasquini, J.M.
Formato: JOUR
Materias:
Axonal growth
Filamentous actin
Galectin-1
Hydrogen peroxide
PlexinA4
Semaphorin3A
Spinal cord injury
F actin
galectin 1
glycan
hydrogen peroxide
neuropilin
plexin
plexin A4
semaphorin 3A
unclassified drug
actin filament
actin polymerization
animal cell
animal experiment
animal model
Article
cell surface
controlled study
convalescence
disease model
embryo
endocytosis
filopodium
growth cone
in vivo study
internalization
male
molecular mechanics
molecular recognition
mouse
nerve cell
nerve fiber regeneration
nonhuman
priority journal
rat
remyelinization
spinal cord injury
synaptogenesis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144886_v283_n_p165_Quinta
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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