A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures

Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradi...

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Detalles Bibliográficos
Autores principales: Cardinali, D.P., Vacas, M.I., Ritta, M.N.
Formato: JOUR
Materias:
5 methoxytryptophol
estradiol
melatonin
puromycin
radioisotope
serotonin
animal experiment
drug metabolism
endocrine system
in vitro study
organ culture
pineal body
rat
Animal
Dose-Response Relationship, Drug
Estradiol
Organ Culture
Pineal Gland
Puromycin
Rats
Serotonin
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144754_v37_n2_p203_Cardinali
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradiol was blocked by the simultaneous addition of puromycin in the culture medium. © 1981 Birkhäuser Verlag.

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