Is tubulin involved in the electrically-induced mechanical activity of the isolated rat sciatic nerve?

The electrically-induced mechanical activity of isolated segments of rat sciatic nerves remains unaffected following incubation with 10-4 M colchicine, vinblastine or melatonin. Vinblastine depressed tubulin levels in incubated nerves. These results suggest that microtubules are not involved in nerv...

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Detalles Bibliográficos
Autores principales: Valenti, C.E., de Gimeno, M.F., Cardinali, D.P., Gimeno, A.L.
Formato: JOUR
Materias:
colchicine
melatonin
tubulin
vinblastine
animal experiment
in vitro study
kidney tubule
nerve contraction
nerve stimulation
nervous system
peripheral nervous system
rat
sciatic nerve
Animal
Colchicine
Electric Stimulation
Melatonin
Rats
Sciatic Nerve
Tubulin
Vinblastine
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144754_v36_n4_p425_Valenti
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The electrically-induced mechanical activity of isolated segments of rat sciatic nerves remains unaffected following incubation with 10-4 M colchicine, vinblastine or melatonin. Vinblastine depressed tubulin levels in incubated nerves. These results suggest that microtubules are not involved in nerve mechanical activity in vitro. © 1980 Birkhäuser Verlag.

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