Quercetin antagonism of GABAAρ1 receptors is prevented by ascorbic acid through a redox-independent mechanism

Quercetin is a natural flavonoid widely distributed in plants that acts as a neuroprotective agent and modulates the activity of different synaptic receptors and ion channels, including the ionotropic GABA receptors. GABA Aρ1 receptors were shown to be antagonized by quercetin, but the mechanisms un...

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Detalles Bibliográficos
Autores principales: Calero, C.I., González, A.N.B., Gasulla, J., Alvarez, S., Evelson, P., Calvo, D.J.
Formato: JOUR
Materias:
Allosteric modulator
Ascorbic acid
Flavonoid
GABA receptor
Quercetin
4 aminobutyric acid
4 aminobutyric acid A receptor
4 aminobutyric acid A receptor blocking agent
4 aminobutyric acid receptor
ascorbic acid
flavonoid
histidine
quercetin
γ-aminobutyric acid
allosterism
animal
article
chemistry
dose response
drug antagonism
drug effect
human
metabolism
N-ethylmaleimide
NEM
antagonists and inhibitors
drug effects
GABA
Allosteric Regulation
Animals
Ascorbic Acid
Dose-Response Relationship, Drug
GABA-A Receptor Antagonists
Histidine
Humans
Receptors, GABA-A
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00142999_v714_n1-3_p274_Calero
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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