Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: Role of oestrogens

Anandamide (0.01 to 10 μM) caused greater concentration-dependent reductions of the contractile-induced responses to noradrenaline in female than in male mesenteric vascular beds isolated from adult Sprague-Dawley rats. Greater relaxant responses in females were also induced by the vanilloid TRPV1 r...

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Detalles Bibliográficos
Autores principales:	Peroni, R.N., Orliac, M.L., Becu-Villalobos, D., Huidobro-Toro, J.P., Adler-Graschinsky, E., Celuch, S.M.
Formato:	JOUR
Materias:	(Sprague-Dawley rat) 17β-Oestradiol Anandamide Sex difference Vasorelaxation acetylcholine anandamide cannabinoid 1 receptor cannabinoid receptor antagonist capsaicin capsazepine cycloheximide estradiol estradiol benzoate estrogen nitroprusside sodium noradrenalin protein synthesis inhibitor rimonabant vanilloid receptor animal experiment animal tissue article blood vessel concentration response controlled study dose response drug effect estrogen activity exposure female in vitro study isolated organ male muscle contractility nonhuman ovariectomy priority journal rat sex difference vasodilatation Acetylcholine Animals Arachidonic Acids Argentina Capsaicin Chile Cycloheximide Dose-Response Relationship, Drug Drug Synergism Estradiol Estrogens Female Male Mesentery Muscle, Smooth, Vascular Nitroprusside Norepinephrine Ovariectomy Phenylmethylsulfonyl Fluoride Piperidines Polyunsaturated Alkamides Pyrazoles Rats Rats, Sprague-Dawley Sex Characteristics Time Factors Vasodilation
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00142999_v493_n1-3_p151_Peroni
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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