Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model

Polycystic ovary syndrome (PCOS) is a frequent pathology that affects more than 5% of women of reproductive age. Among other heterogeneous symptoms, PCOS is characterized by abnormalities in angiogenesis. Metformin has been introduced in the treatment of PCOS to manage insulin resistance and hypergl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Di Pietro, M., Parborell, F., Irusta, G., Pascuali, N., Bas, D., Bianchi, M.S., Tesone, M., Abramovich, D.
Formato:	JOUR
Materias:	angiopoietin 1 angiopoietin 2 insulin metformin platelet derived growth factor B platelet derived growth factor D prasterone vasculotropin vasculotropin receptor 2 angiogenesis modulator platelet derived growth factor vasculotropin A angiogenesis animal experiment animal model Article birth rate cell structure controlled study corpus luteum female glucose metabolism hyperglycemia insulin blood level insulin resistance live birth nonhuman ovary follicle cell ovary polycystic disease ovulation pregnancy priority journal protein expression rat animal blood drug effects metabolism Neovascularization, Pathologic ovary follicle pathophysiology Polycystic Ovary Syndrome Sprague Dawley rat Angiogenesis Modulating Agents Angiopoietin-1 Angiopoietin-2 Animals Dehydroepiandrosterone Female Insulin Insulin Resistance Metformin Ovarian Follicle Platelet-Derived Growth Factor Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00137227_v156_n4_p1453_DiPietro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model
por: di Pietro, María Florencia, et al.
Publicado: (2015)

Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome
Publicado: (2012)

Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome
por: Abramovich, D., et al.

Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
por: di Pietro, María Florencia, et al.
Publicado: (2016)

Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
por: Di Pietro, M., et al.

Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)
Publicado: (2013)

Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)
por: Scotti, L., et al.

Spatiotemporal analysis of the protein expression of angiogenic factors and their related receptors during folliculogenesis in rats with and without hormonal treatment
por: Abramovich, Dalhia Nurit, et al.
Publicado: (2009)

Spatiotemporal analysis of the protein expression of angiogenic factors and their related receptors during folliculogenesis in rats with and without hormonal treatment
por: Abramovich, D., et al.

Platelet-derived growth factor BB and DD and angiopoietin1 are altered in follicular fluid from polycystic ovary syndrome patients
Publicado: (2014)

Platelet-derived growth factor BB and DD and angiopoietin1 are altered in follicular fluid from polycystic ovary syndrome patients
por: Scotti, L., et al.

Regulation of ovarian angiogenesis and apoptosis by GnRH-I analogs
por: Parborell, M.Fernanda A., et al.
Publicado: (2008)

Regulation of ovarian angiogenesis and apoptosis by GnRH-I analogs
por: Parborell, F., et al.

Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats
Publicado: (2015)

Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats
por: Pascuali, N., et al.

Angiopoietin 1 reduces rat follicular atresia mediated by apoptosis through the PI3K/Akt pathway
Publicado: (2011)

Angiopoietin 1 reduces rat follicular atresia mediated by apoptosis through the PI3K/Akt pathway
por: Parborell, F., et al.

Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes
por: Parborell, M.Fernanda A., et al.
Publicado: (2008)

Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes
por: Parborell, F., et al.
Publicado: (2008)

Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes
por: Parborell, F., et al.

Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes
por: Parborell, F., et al.
Publicado: (2008)

Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
por: Abramovich, Dalhia Nurit, et al.
Publicado: (2014)

Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
por: Scotti, L., et al.

Administration of a gonadotropin-releasing hormone agonist affects corpus luteum vascular stability and development and induces luteal apoptosis in a rat model of ovarian hyperstimulation syndrome
por: Irusta, Griselda, et al.
Publicado: (2011)

Administration of a gonadotropin-releasing hormone agonist affects corpus luteum vascular stability and development and induces luteal apoptosis in a rat model of ovarian hyperstimulation syndrome
por: Scotti, L., et al.

Altered expression of Bcl-2 and Bax in follicles within dehydroepiandrosterone-induced polycystic ovaries in rats
por: Abramovich, Dalhia Nurit, et al.
Publicado: (2011)

Altered expression of Bcl-2 and Bax in follicles within dehydroepiandrosterone-induced polycystic ovaries in rats
por: Bas, D., et al.

InVet. 2019, 21 (1): 27-34 ANGIOGÉNESIS PLACENTARIA CAPRINA ISSN 1514-6634...
por: Mura, N., et al.
Publicado: (2019)

Polycystic ovarian syndrome: temporal characterization of the induction and reversion process in an experimental model
por: Salvetti, Natalia Raquel, et al.
Publicado: (2004)

Gonadotropin-releasing hormone agonist affects rat ovarian follicle development by interfering with FSH and growth factors on the prevention of apoptosis
por: Parborell, M.Fernanda A., et al.
Publicado: (2001)

Gonadotropin-releasing hormone agonist affects rat ovarian follicle development by interfering with FSH and growth factors on the prevention of apoptosis
por: Parborell, F., et al.

Interaction between IGF1 and IGFBPs in bovine cystic ovarian disease
por: Rodríguez, Fernanda Mariel, et al.
Publicado: (2013)

Leptina en pacientes con s�indrome de ovario poliqu�istico correlaci�on directa con la resistencia insul�inica /
por: Calvar, Cecilia E, et al.
Publicado: (2003)

Polycystic ovary syndrome: physiopathology review
por: Fux Otta, Carolina, et al.
Publicado: (2013)

Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats
Publicado: (2006)

Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats
por: Abramovich, D., et al.

Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS)
por: Abramovich, Dalhia Nurit, et al.
Publicado: (2016)

Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS)
por: Scotti, L., et al.

Inhibin A increases apoptosis in early ovarian antral follicles of diethylstilbestrol-treated rats
Publicado: (2002)

Inhibin A increases apoptosis in early ovarian antral follicles of diethylstilbestrol-treated rats
por: Vitale, A.M., et al.