Reduced expression of the cytokine transducer gp130 inhibits hormone secretion, cell growth, and tumor development of pituitary lactosomatotrophic GH3 cells

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Two of the most potent cytokines that regulate anterior pituitary cell function are leukemia inhibitory factor and IL-6. These and others like IL-11 and ciliary neurotrophic factor are referred to as the gp130 cytokines because they share the gp130 glycoprotein as a common receptor initial signal tr...

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Detalles Bibliográficos
Autores principales: Perez Castro, C., Giacomini, D., Carbia Nagashima, A., Onofri, C., Graciarena, M., Kobayashi, K., Páez-Pereda, M., Renner, U., Stalla, G.K., Arzt, E.
Formato: JOUR
Materias:
antisense oligodeoxynucleotide
complementary DNA
cytokine
glycoprotein gp 130
interleukin 11
interleukin 6
leukemia inhibitory factor
adenohypophysis
animal cell
article
carcinogenesis
cell function
cell growth
cell proliferation
cell strain GH3
clone
controlled study
gene expression
gene overexpression
genetic transfection
growth hormone release
hormone release
hypophysis cell
nonhuman
nude mouse
priority journal
prolactin release
prolactin synthesis
rat
signal transduction
transcription initiation
Animals
Antigens, CD
Cell Division
Cytokine Receptor gp130
Cytokines
Gene Expression Regulation, Neoplastic
Hormones
Membrane Glycoproteins
Mice
Mice, Nude
Neoplasm Transplantation
Pituitary Neoplasms
Rats
RNA, Messenger
Tumor Cells, Cultured
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v144_n2_p693_PerezCastro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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