Inhibition of calcium-calmodulin kinase restores nitric oxide production and signaling in submandibular glands of a mouse model of salivary dysfunction

Nitric oxide is an intracellular and diffusible messenger of neurotransmitters involved in salivary secretion, as well as an inflammatory mediator in salivary gland diseases. It is synthesized by three different isoforms of nitric oxide synthase (NOS), each subject to a fine transcriptional, post-tr...

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Detalles Bibliográficos
Autores principales: Rosignoli, F., Roca, V., Meiss, R., Pregi, N., Pérez Leirós, C.
Formato: JOUR
Materias:
CaM kinase inhibition
KN-93
NOD mice
NOS regulation
Salivary dysfunction
arginase
bisindolylmaleimide
complementary DNA
cyclic GMP
glyceraldehyde 3 phosphate dehydrogenase
messenger RNA
n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino]methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide
n(g) methylarginine
nitric oxide
nitric oxide synthase inhibitor
protein kinase (calcium,calmodulin)
protein kinase inhibitor
animal model
animal tissue
article
DNA synthesis
down regulation
enzyme assay
enzyme inhibition
immunohistochemistry
mouse
nonhuman
priority journal
protein expression
reverse transcription polymerase chain reaction
salivary gland
signal transduction
submandibular gland
Western blotting
Animals
Ca(2+)-Calmodulin Dependent Protein Kinase
Disease Models, Animal
Female
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
Nitric Oxide
Protein Kinase Inhibitors
Salivary Gland Diseases
Signal Transduction
Submandibular Gland
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00071188_v143_n8_p1058_Rosignoli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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