Porphyrin synthesis from ALA derivatives for photodynamic therapy. In vitro and in vivo studies

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The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a m...

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Detalles Bibliográficos
Autores principales: Perotti, C., Fukuda, H., DiVenosa, G., MacRobert, A.J., Batlle, A., Casas, A.
Formato: JOUR
Materias:
ALA
ALA derivatives
Aminolevulinic acid
PDT
Photodynamic therapy
2 (hydroxymethyl)tetrahydropyranyl 5 aminolevulinic acid
aminolevulinic acid
hexyl 5 aminolevulinic acid
photosensitizing agent
porphyrin
unclassified drug
undecanoyl 5 aminolevulinic acid
drug derivative
animal cell
animal experiment
animal model
animal tissue
article
bioaccumulation
breast tumor
cell line
controlled study
correlation analysis
drug determination
drug efficacy
drug uptake
explant
ion exchange chromatography
male
mouse
nonhuman
photodynamic therapy
phototoxicity
porphyrin metabolism
priority journal
animal
Bagg albino mouse
biosynthesis
chemistry
experimental neoplasm
methodology
photochemotherapy
Aminolevulinic Acid
Animals
Male
Mammary Neoplasms, Animal
Mice
Mice, Inbred BALB C
Photochemotherapy
Photosensitizing Agents
Porphyrins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00070920_v90_n8_p1660_Perotti
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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