Circadian rhythm and neural regulation of rat pineal angiotensin converting enzyme

Angiotensin converting enzyme was detectable in rat pineal gland and exhibited a circadian rhythm in activity with maximum at the end of the light phase of daily photoperiod. Superior cervical ganglionectomy (SCGx) or exposure to light for 6 days increased enzyme activity and obliterated morning-eve...

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Detalles Bibliográficos
Autores principales: Nahmod, V.E., Balda, M.S., Pirola, C.J., Finkielman, S., Gejman, P.V., Cardinali, D.P.
Formato: JOUR
Materias:
angiotensin
angiotensin converting enzyme
Captopril
circadian rhythms
norepinephrine
pineal gland
superior cervical ganglia
captopril
dipeptidyl carboxypeptidase
isoprenaline
noradrenalin
sq 14,225
unclassified drug
animal experiment
autonomic nervous system
circadian rhythm
endocrine system
pineal body
rat
superior cervical ganglion
Animals
Circadian Rhythm
Ganglia, Sympathetic
Isoproterenol
Light
Male
Norepinephrine
Peptidyl-Dipeptidase A
Pineal Gland
Rats
Rats, Inbred Strains
Receptors, Adrenergic, beta
Spinal Cord
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00068993_v236_n1_p216_Nahmod
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Angiotensin converting enzyme was detectable in rat pineal gland and exhibited a circadian rhythm in activity with maximum at the end of the light phase of daily photoperiod. Superior cervical ganglionectomy (SCGx) or exposure to light for 6 days increased enzyme activity and obliterated morning-evening differences, whereas injection of the β-agonist isoproterenol depressed the high values observed in SCGx animals. These results indicate that angiotensin converting enzyme in the pineal gland is under negative control by the norepinephrine released from pineal sympathetic nerves. © 1982.

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