Effects of an inhibitor of the gamma-secretase complex on proliferation and apoptotic parameters in a foxl2-mutated granulosa tumor cell line (KGN)

Ovarian granulosa cell tumors (GCTs) represent 3%-5% of all ovarian malignancies. Treatments have limited proven efficacy and biologically targeted treatment is lacking. The aim of this study was to investigate the role of Notch signaling in the proliferation, steroidogenesis, apoptosis, and phospha...

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Detalles Bibliográficos
Autores principales:	Irusta, G., Maidana, C.P., Abramovich, D., De Zúñiga, I., Parborell, F., Tesone, M.
Formato:	JOUR
Materias:	Apoptosis Kgn cells Notch system Pi3K/akt signaling caspase 8 Fas antigen Fas ligand gamma secretase inhibitor Jagged1 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase Notch receptor Notch1 receptor Notch4 receptor phosphatidylinositol 3 kinase phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase presenilin progesterone protein Bax protein bcl 2 protein bcl xl protein kinase B transcription factor transcription factor foxl2 unclassified drug adult apoptosis article cell death cell growth cell proliferation cell survival cell viability complex formation controlled study extracellular matrix female gene mutation granulosa cell tumor human human cell infertility therapy luteal cell priority journal protein cleavage protein dephosphorylation protein domain protein expression protein phosphorylation protein protein interaction signal transduction steroidogenesis tumor cell line KGN cells PI3K/AKT signaling Amyloid Precursor Protein Secretases Calcium-Binding Proteins Cell Line, Tumor Cell Proliferation Dipeptides Female Forkhead Transcription Factors Gonadal Steroid Hormones Granulosa Cell Tumor Humans Intercellular Signaling Peptides and Proteins Membrane Proteins Mutation Ovarian Neoplasms Receptors, Notch
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00063363_v89_n1_p_Irusta
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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