Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus

Consolidation of long-term memory requires the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and to regulation of gene expression, both of which promote stabilization of specific changes in the activated circuits. In search of the mole...

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Detalles Bibliográficos
Autores principales: Romano, A., Locatelli, F., Freudenthal, R., Merlo, E., Feld, M., Ariel, P., Lemos, D., Federman, N., Fustiñana, M.S.
Formato: JOUR
Materias:
amyloid precursor protein
cyclic AMP dependent protein kinase
immunoglobulin enhancer binding protein
mitogen activated protein kinase
crab
enzyme activity
gene expression
memory
protein
animal
animal model
biological model
Brachyura
metabolism
physiology
review
signal transduction
synaptic transmission
Amyloid beta-Protein Precursor
Animals
Cyclic AMP-Dependent Protein Kinases
Extracellular Signal-Regulated MAP Kinases
Memory
Models, Animal
Models, Neurological
NF-kappa B
Signal Transduction
Synaptic Transmission
Chasmagnathus
Decapoda (Crustacea)
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00063185_v210_n3_p280_Romano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Consolidation of long-term memory requires the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and to regulation of gene expression, both of which promote stabilization of specific changes in the activated circuits. In search of the molecular mechanisms involved in such processes, we used the context-signal associative learning paradigm of the crab Chasmagnathus. In this model, we studied the role of some molecular mechanisms, namely cAMP-dependent protein kinase (PKA), extracellular-signal-regulated kinase (ERK), the nuclear factor kappa B (NF-κB) transcription factor, and the role of synaptic proteins such as amyloid β precursor protein, with the object of describing key mechanisms involved in memory processing. In this article we review the most salient results obtained over a decade of research in this memory model. © 2006 Marine Biological Laboratory.

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