Molecular Basis of Hydroperoxide Specificity in Peroxiredoxins: The Case of AhpE from Mycobacterium tuberculosis

Peroxiredoxins (Prxs) constitute a ubiquitous family of Cys-dependent peroxidases that play essential roles in reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides in almost all organisms. Members of the Prx subfamilies show differential oxidizing substrate specificities that await...

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Detalles Bibliográficos
Autores principales: Zeida, A., Reyes, A.M., Lichtig, P., Hugo, M., Vazquez, D.S., Santos, J., González Flecha, F.L., Radi, R., Estrin, D.A., Trujillo, M.
Formato: JOUR
Materias:
Dimers
Enzymes
Free energy
Hydrogen peroxide
Hydrophobicity
Oxidation
Peroxides
Plants (botany)
Activation entropies
Alkyl hydroperoxide
Arachidonic acids
Computational dynamics
Mycobacterium tuberculosis
Organic hydroperoxides
Oxidizing substrates
Reaction free energy
Fatty acids
arachidonic acid
fatty acid
hydrogen peroxide
hydroperoxide
hydroperoxide reductase e
peroxiredoxin
unclassified drug
bacterial protein
Article
binding site
catalysis
conformational transition
controlled study
crystal structure
crystallography
entropy
enzyme activity
enzyme specificity
molecular dynamics
nonhuman
priority journal
protein conformation
protein expression
quantum yield
chemistry
enzymology
protein multimerization
Bacterial Proteins
Molecular Dynamics Simulation
Peroxiredoxins
Protein Multimerization
Substrate Specificity
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00062960_v54_n49_p7237_Zeida
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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