Hexachlorobenzene as hormonal disruptor-studies about glucocorticoids: Their hepatic receptors, adrenal synthesis and plasma levels in relation to impaired gluconeogenesis

In Wistar rats, hexachlorobenzene (HCB) depresses the gluconeogenic enzyme phosphoenolpyruvate-carboxykinase (PEPCK). In the liver, glucocorticoids (GC) normally regulate the glucose synthesis by acting on PEPCK. Thus, the aim of this work was to investigate, in a time-course study, the effects of H...

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Detalles Bibliográficos
Autores principales: Lelli, S.M., Ceballos, N.R., Mazzetti, M.B., Aldonatti, C.A., San Martín de Viale, L.C.
Formato: JOUR
Materias:
Corticosterone
Glucocorticoids receptor
Gluconeogenesis
Hexachlorobenzene
Phosphoenol-pyruvate carboxykinase
Porphyria
allylisopropylacetamide
corticosterone
corticotropin
glucocorticoid receptor
glucose
griseofulvin
hexachlorobenzene
phosphoenolpyruvate carboxykinase (GTP)
reduced nicotinamide adenine dinucleotide
steroid hormone
adrenal gland
animal experiment
article
binding affinity
biosynthesis
controlled study
corticosterone blood level
female
gluconeogenesis
intoxication
nonhuman
pest control
porphyria
priority journal
radioimmunoassay
rat
receptor binding
urine level
xenobiotic metabolism
Adrenal Glands
Animals
Endocrine Disruptors
Female
Liver
Phosphoenolpyruvate Carboxykinase (ATP)
Porphyrins
Rats
Rats, Wistar
Receptors, Glucocorticoid
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00062952_v73_n6_p873_Lelli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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