Structural and mechanistic comparison of the Cyclopropane Mycolic Acid Synthases (CMAS) protein family of Mycobacterium tuberculosis

Tuberculosis (TB) is a chronic disease caused by the bacillus Mycobacterium tuberculosis(Mtb) and remains a leading cause of mortality worldwide. The bacteria has an external wall which protects it from being killed, and the enzymes involved in the biosynthesis of the cell wall components have been...

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Detalles Bibliográficos
Autores principales: Defelipe, L.A., Osman, F., Marti, M.A., Turjanski, A.G.
Formato: JOUR
Materias:
Bioinformatics
CMAS
Methyltransferase
Mycolic acids
QM/MM
Tuberculosis
bacterial enzyme
cyclopropane mycolic acid synthase
protein cmaA2
protein mmaA1
protein mmaA4
unclassified drug
bacterial protein
bicarbonate
cyclopropane
cyclopropane derivative
methyltransferase
mixed function oxidase
mma4 protein, Mycobacterium tuberculossis
amino acid sequence
Article
comparative study
energy
enzyme activity
enzyme mechanism
enzyme structure
enzyme substrate complex
molecular docking
molecular model
Mycobacterium tuberculosis
nonhuman
priority journal
structure activity relation
chemistry
enzyme active site
enzymology
metabolism
molecular dynamics
Bacterial Proteins
Bicarbonates
Catalytic Domain
Cyclopropanes
Methyltransferases
Mixed Function Oxygenases
Models, Molecular
Molecular Docking Simulation
Molecular Dynamics Simulation
Structure-Activity Relationship
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0006291X_v498_n2_p288_Defelipe
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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