MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells

Leptin, the LEP gene product, is produced in placenta where it has been found to be an important autocrine signal for trophoblastic growth during pregnancy. Thus, we have recently described the antiapoptotic and trophic effect of leptin on choriocarcinoma cell line JEG-3, stimulating DNA and protein...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Pérez-Pérez, A., Gambino, Y., Maymó, J., Goberna, R., Fabiani, F., Varone, C., Sánchez-Margalet, V.
Formato: JOUR
Materias:
Leptin
Placenta
Protein synthesis
Signal transduction
Translation
DNA
initiation factor 4E
initiation factor 4E binding protein 1
Janus kinase
leptin
leptin receptor
leucine
mitogen activated protein kinase
phosphatidylinositol 3 kinase
protein kinase B
S6 kinase
STAT protein
tritium
apoptosis
article
autocrine effect
cell growth
choriocarcinoma
controlled study
DNA synthesis
enzyme activation
enzyme activity
enzyme inhibition
genetic transfection
human
human cell
pregnancy
priority journal
protein phosphorylation
protein synthesis
protein synthesis inhibition
protein synthesis regulation
signal transduction
translation initiation
trophoblast
1-Phosphatidylinositol 3-Kinase
Adaptor Proteins, Signal Transducing
Cell Line, Tumor
Eukaryotic Initiation Factor-4E
Female
Humans
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Phosphoproteins
Phosphorylation
Pregnancy
Protein Biosynthesis
Proto-Oncogene Proteins c-akt
Ribosomal Protein S6 Kinases, 70-kDa
Trophoblasts
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0006291X_v396_n4_p956_PerezPerez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares