Mapping of the protein-binding interface between splicing factors SF3b155 and p14 of Trypanosoma cruzi

SF3b155 and p14 are essential components of spliceosome core that recognize the branch point adenosine, a critical step in splicing in eukaryotes. Trypanosomes are unusual since every transcribed gene is processed by trans-splicing instead of cis-splicing. Thus, the trans-spliceosome emerges as an i...

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Detalles Bibliográficos
Autores principales: Avila, M.L., Bercovich, N., Westergaard, G., Levin, M.J., Vázquez, M.P.
Formato: JOUR
Materias:
Drug targets
Protein interaction
Trans-splicing
alanine
messenger RNA
protein derivative
protein p14
SF3b155 protein
unclassified drug
article
DNA splicing
gene mapping
nonhuman
priority journal
protein binding
protein processing
spliceosome
Trypanosoma
Trypanosoma cruzi
Amino Acid Sequence
Animals
Humans
Molecular Sequence Data
Nuclear Magnetic Resonance, Biomolecular
Phosphoproteins
Protein Binding
Protein Structure, Tertiary
Protozoan Proteins
Ribonucleoprotein, U2 Small Nuclear
RNA-Binding Proteins
Spliceosomes
Eukaryota
Mammalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0006291X_v364_n1_p26_Avila
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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